منابع مشابه
Variants of asthma and chronic obstructive pulmonary disease genes and lung function decline in aging.
BACKGROUND A substantial proportion of the general population has low lung function, and lung function is known to decrease as we age. Low lung function is a feature of several pulmonary disorders, such as uncontrolled asthma and chronic obstructive pulmonary disease. The objective of this study is to investigate the association of polymorphisms in asthma and chronic obstructive pulmonary disea...
متن کاملLung function decline in asthma.
P rogressive decline in lung function in asthma has been well recognised but not fully explained. For example, in a Danish population study (the Copenhagen City Heart Study), three measurements of forced expiratory volume in one second (FEV1) were made over 15 yrs in 17,506 subjects, including 1,095 with asthma [1]. Asthmatics showed a decline in FEV1 of 38 mL?yr compared with 22 mL?yr in norma...
متن کاملLung function decline in COPD
The landmark study of Fletcher and Peto on the natural history of tobacco smoke-related chronic airflow obstruction suggested that decline in the forced expiratory volume in the first second (FEV(1)) in chronic obstructive pulmonary disease (COPD) is slow at the beginning, becoming faster with more advanced disease. The present authors reviewed spirometric data of COPD patients included in the ...
متن کاملNFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease.
An oxidant-antioxidant imbalance in the lung contributes to the development of chronic obstructive pulmonary disease (COPD) that is caused by a complex interaction of genetic and environmental risk factors. Nuclear erythroid 2-related factor 2 (NFE2L2 or NRF2) is a critical molecule in the lung's defense mechanism against oxidants. We investigated whether polymorphisms in the NFE2L2 pathway aff...
متن کاملCHRONIC OBSTRUCTIVE PULMONARY DISEASE Lung function decline and outcomes in an elderly population
Objective: To determine the risk factors for and outcomes associated with the rapid decline in lung function in a cohort of elderly US adults. Methods: Data from 4923 adult participants aged 65 years and older at baseline in the Cardiovascular Health Study were analysed. Subjects were classified using a modification of the GOLD criteria for chronic obstructive pulmonary disease (COPD) and a ‘‘r...
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ژورنال
عنوان ژورنال: Chronic Respiratory Disease
سال: 2016
ISSN: 1479-9731,1479-9731
DOI: 10.1177/1479972316628534